(R)-SCH 42495 is the less active enantiomer of SCH 42495^[1]. SCH 42495 is an orally active neutral metalloendopeptidase (NEP) inhibitor with antihypertensive effect. SCH 42495 is the orally active ethylester prodrug of SCH 42354^[2].

NEP acts as a critical enzyme in the degradation. NEP cleaves atrial natriuretic factors (ANF) in vitro^[1].

Inhibition of NEP in vivo has been shown to produce beneficial vasodilatory and natriuretic responses^[1].

411.58

C₂₀H₂₉NO₄S₂

156792-25-5

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.