FKGK11

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FKGK11

本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。

CAS NO:

1071000-98-0

FKGK11 是一种有效的且选择性的GVIA iPLA2(VIA 组非钙依赖性磷脂酶 A2) 的抑制剂。FKGK11 可用于卵巢癌和周围神经损伤、多发性硬化等神经系统疾病的研究。

生物活性

FKGK11 is a potent and selective inhibitor ofGVIA iPLA2(Group VIA calcium-independentphospholipaseA2). FKGK11 can be used for the research of ovariancancerand neurological disorders such as peripheral nerve injury and multiple sclerosis^[1]^[2].

IC₅₀& Target

PLA2

体外研究
(In Vitro)

FKGK11 shows 99.4 ± 0.1% inhibition of GVIA iPLA2 and only 28 ± 1% for GV sPLA2 at 0.091 mole fraction^[1].
FKGK11 reduces adhesion, migration, and invasion of EOC (epithelial ovarian cancer) cells^[2].

体内研究
(In Vivo)

FKGK11 inhibits tumor development in the xenograft mouse model^[2].
FKGK11 shows a significant increase in the number of macrophages and degenerating fibres with disrupted myelin sheaths in cPLA2 GIVA–/– mice and C57BL/6 mice^[3].

分子量

280.23

Formula

C₁₃H₁₃F₅O

CAS 号

1071000-98-0

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.