(2E)-OBAA

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(2E)-OBAA

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CAS NO:

221632-26-4

(2E)-OBAA 是一种有效的磷脂酶 A2 (PLA2) 抑制剂，IC₅₀为 70 nM。(2E)-OBAA 诱导 HUVEC 细胞凋亡 (apoptosis)。(2E)-OBAA 在布氏锥虫中阻断 Melittin 诱导的 Ca²⁺流入，IC₅₀为 0.4 μM。

生物活性

(2E)-OBAA is a potentphospholipaseA2 (PLA2)inhibitor, with anIC₅₀of 70 nM. (2E)-OBAA inducesapoptosisof HUVEC cells. (2E)-OBAA blocks Melittin-induced Ca²⁺influx inTrypanosomabrucei, with anIC₅₀of 0.4 μM^[1]^[2]^[3]^[4].

IC₅₀& Target

PLA2

70 nM (IC₅₀)

体外研究
(In Vitro)

(2E)-OBAA (5.7 μM) induces apoptotic cell death of human umbilical vein endothelial cells (HUVEC). After 16 h of treatment, almost all of the cells has disintegrated into apoptotic bodies^[1].

体内研究
(In Vivo)

(2E)-OBAA (2.5-7 mg/kg, IV) significantly and dose-dependently inhibits the immunologically induced bronchospasm in guinea pigs^[3].

分子量

428.65

Formula

C₂₈H₄₄O₃

CAS 号

221632-26-4

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.