20S Proteasome activator 1

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CAS NO:

2761578-18-9

20S Proteasome activator 1 是一种有效的20S 蛋白酶激活剂，对胰蛋白酶样位点、胰凝乳蛋白酶样位点和半胱天冬酶位点的IC₅₀分别为 0.3 μM、0.7 μM 和 1.8 μM。20S Proteasome activator 1 能在细胞系统中翻译，防止致病性 α-synuclein A53T 突变体积累。20S Proteasome activator 1 可用于神经退行性疾病的研究。

生物活性	20SProteasomeactivator 1 is a potent20Sproteasomeactivator withEC₂₀₀values of 0.3 μM, 0.7 μM and 1.8 μM for trypsin-like site, chymotrypsin-like site and caspase-like site. 20SProteasomeactivator 1 translates well in a cellular system, preventing the accumulation of the pathogenic A53T mutant ofα-synuclein. 20SProteasomeactivator 1 can be used for researching neurodegenerative diseases^[1].
IC₅₀& Target	IC₅₀: 0.3 μM (trypsin-like site), 0.7 μM (chymotrypsin-like site), 1.8 μM (caspase-like site)^[1]
体外研究 (In Vitro)	20S Proteasome activator 1 (compound 19) (2.5-15 μM; 45 min) degrades 73% α-synuclein at 10 μM, and over 80% at 15 μM^[1]. 20S Proteasome activator 1 (5-15 μM; 24 h) reduces 25% A53T mutant, and dose-dependently reduces enhancement of α-synuclein in Hek-293T cells (transiently transfected with an A53T mutant α-synuclein plasmid) at 5 μM; decreases 67% A53T α-synuclein at 15 μM^[1].
分子量	492.97
Formula	C₂₇H₁₉ClF₂N₂OS
CAS 号	2761578-18-9
运输条件	Room temperature in continental US; may vary elsewhere.
储存方式	Please store the product under the recommended conditions in the Certificate of Analysis.