CD12681

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CD12681

本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。

CAS NO:

1952239-59-6

CD12681 (compound 14) 是一种有效的选择性RORγ反向激动剂，对 RORγ GAL4 细胞和 CD4-IL-17 的IC₅₀分别为 19 nM 和 10 nM。CD12681 减少 IL-17 炎症细胞募集。CD12681 具有银屑病研究的潜力。

生物活性

CD12681 (compound 14) is a potent and selectiveRORγinverse agonist withIC₅₀of 19 nM and 10 nM forRORγGAL4 and CD4-IL-17 cells, respectively. CD12681 decreases theIL-17inflammatory cell recruitment. CD12681 has the potential for the research of psoriasis^[1].

IC₅₀& Target^[1]

RORγ

体外研究
(In Vitro)

CD12681 (compound 14) shows inhibition with IC₅₀s of 44, >25, 9 μM for CYP 3A4, CYP 2D6, hERG, respectively^[1].

分子量

471.61

Formula

C₂₅H₃₃N₃O₄S

CAS 号

1952239-59-6

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.