5-epi-Arvestonate A

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5-epi-Arvestonate A

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CAS NO:

2767066-84-0

5-epi-Arvestonate A 是一种从绢毛菊 (Seriphidium transiliense) 中分离得到的倍半萜类化合物。5-epi-Arvestonate A 通过激活小眼相关转录因子 (MITF) 和酪氨酸酶家族基因的转录，促进黑色素生成。5-epi-Arvestonate A 通过 JAK/STAT 信号通路抑制永生化人角化细胞 (HaCaT) 中 IFN-γ 趋化因子的表达。

生物活性

5-epi-Arvestonate A is a sesquiterpenoid isolated from the wholeplantsofSeriphidium transiliense. 5-epi-Arvestonate A promotes melanogenic production by activating the transcription of microphthalmia-associated transcription factor (MITF) andtyrosinasefamily genes. 5-epi-Arvestonate A inhibits the expression of IFN-γ-chemokine through theJAK/STAT signalingpathway in immortalized human keratinocyte (HaCaT) cells^[1].

体外研究
(In Vitro)

5-epi-Arvestonate A (50 μM; 48 h) activates the transcription of microphthalmia-associated transcription factor (MITF) and tyrosinase family genes in murine melanoma (B16) cells^[1].
5-epi-Arvestonate A (50 μM; 48 h) increases both the mRNA and protein level of TRP-1, TRP-2, TYR, and MITF in murine melanoma (B16) cells^[1].
5-epi-Arvestonate A (10 μM, 50 μM; 24 h) disrupts the IFN-γ-chemokine and CXCL10/9 production through the JAK/STAT signal pathway in IFN-γ-activated HaCaT cells^[1].

Western Blot Analysis^[1]

Cell Line:	Murine melanoma (B16) cells; IFN-γ-activated HaCaT cells
Concentration:	1, 10, 50 μM
Incubation Time:	24 hours and 48 hours
Result:	Increased the protein level of TRP-1, TRP-2, TYR, and MITF at 50 μM concentration in murine melanoma (B16) cells. Decreased the protein level of IFN-γ, CXCL9/10 in IFN-γ-activated HaCaT cells for 24 hr.

Cell Viability Assay^[1]

Cell Line:	Murine melanoma (B16) cells
Concentration:	1, 10, 50 μM
Incubation Time:	48 hours
Result:	Increased the viability of B16, increased the levels of both relative melanin content and relative tyrosinase activity.

分子量

298.37

Formula

C₁₆H₂₆O₅

CAS 号

2767066-84-0

结构分类

Terpenoids
Sesquiterpenes

来源

Seriphidium transiliense

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.