Cyclo(his-pro)(Cyclo(histidyl-proline))

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本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。

CAS NO:

53109-32-3

包装与价格：

包装	价格(元)
10mM (in 1mL Water)	询价
25mg	询价
50mg	询价
100mg	询价

Cyclo(his-pro) (Cyclo(histidyl-proline)) (Cyclo(histidyl-proline)) 是一种具有口服活性的环状二肽，在结构上与促甲状腺激素释放激素有关。

Cas No.	53109-32-3
别名	环(组氨酰-脯氨酰),Cyclo(histidyl-proline); Histidylproline diketopiperazine
Canonical SMILES	Cyclo(His-Pro)
分子式	C₁₁H₁₄N₄O₂
分子量	234.25
溶解度	Water : ≥ 30 mg/mL (128.07 mM)
储存条件	Store at -20°C
General tips	For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping Condition	Evaluation sample solution : ship with blue ice All other available size: ship with RT , or blue ice upon request
产品描述	Cyclo(His-Pro) is a cyclic dipeptide structurally related to tyreotropin-releasing hormone. Cyclo(His-Pro) could inhibit NF-κB nuclear accumulation. Cyclo(His-Pro) is a cyclic dipeptide derived from the hydrolytic removal of the amino-terminal pyroglutamic acid residue of the hypothalamic thyrotropin-releasing hormone. Cyclo(His-Pro) is ubiquitous in the central nervous system and is a key substrate of organic cation transporters, which are strongly linked to neuroprotection. The cyclic dipeptide can also cross the brain-blood-barrier and, once in the brain, can affect diverse inflammatory and stress responses by modifying the Nrf2-NF-κB signaling axis[1]. Cyclo(His-Pro) inhibits NF-κB nuclear accumulation induced by paraquat in rat pheochromocytoma PC12 cells via the Nrf2/heme oxygenase-1 pathway[2]. Mice that receives cyclo(His-Pro) pre-treatment shows a significant decrease in the oedematogenic response, confirming that the cyclic dipeptide can exert anti-inflammatory effect[2]. Cyclo(His-Pro) exerts in vivo anti-inflammatory effects in the central nervous system by down-regulating hepatic and cerebral TNFα expression thereby counteracting LPS-induced gliosis. Moreover, by up-regulating Bip, cyclo(His-Pro) increases the ER stress sensitivity andtriggers the unfolded protein response to alleviate the ER stress[3]. [1]. Grottelli S, et al. The Role of Cyclo(His-Pro) in Neurodegeneration. Int J Mol Sci. 2016 Aug 12;17(8). pii: E1332. [2]. Minelli A, et al. Cyclo(His-Pro) exerts anti-inflammatory effects by modulating NF-κB and Nrf2 signalling. Int J Biochem Cell Biol. 2012 Mar;44(3):525-35. [3]. Bellezza I, et al. Neuroinflammation and endoplasmic reticulum stress are coregulated by cyclo(His-Pro) to prevent LPS neurotoxicity. Int J Biochem Cell Biol. 2014 Jun;51:159-69.