1-Methyl-2-undecyl-4(1H)-quinolone

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CAS NO:

59443-02-6

1-Methyl-2-undecyl-4(1H)-quinolone 是一种有效的不可逆和选择性 B 型单胺氧化酶 (MAO-B) 抑制剂。1-Methyl-2-undecyl-4(1H)-quinolone 对 MAO-B 有选择性抑制作用，IC₅₀和K_i值分别为 15.3 μM和 9.91 μM，但对 A 型 MAO (MAO-A) 活性没有抑制作用。1-Methyl-2-undecyl-4(1H)-quinolone 是一种喹诺酮类生物碱，从Evodia rutaecarpa HOOK. f. et THOMS 鲜叶和果实中分离得到。

生物活性

1-Methyl-2-undecyl-4(1H)-quinolone is a potent, irreversible and selective inhibitor of type Bmonoamine oxidase(MAO-B). 1-Methyl-2-undecyl-4(1H)-quinolone shows a selective inhibition ofMAO-Bactivity with theIC₅₀andK_ivalues of 15.3 μM and 9.91 μM, respectively, but did not inhibit type A MAO (MAO-A) activity. Methyl-2-undecyl-4(1H)-quinolone, as aquinolonealkaloid, is isolated from fresh leaves and fruits of Evodia rutaecarpa HOOK. f. et THOMS^[1]^[2].

IC₅₀& Target^[2]

MAO-B

15.3 μM (IC₅₀)

MAO-B

9.91 μM (Ki)

体外研究
(In Vitro)

1-Methyl-2-undecyl-4(1H)-quinolone shows a selective inhibition of MAO-B activity with the IC₅₀and K_ivalues of 15.3 μM and 9.91 μM, respectively, but did not inhibit type A MAO (MAO-A) activity^[2].

分子量

313.48

Formula

C₂₁H₃₁NO

CAS 号

59443-02-6

结构分类

Alkaloids
Quinoline Alkaloids

来源

Plants
Rutaceae
Evodia rutaecarpa(Juss.) Benth.

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.