Monoamine OxidaseB inhibitor 1 is a potent, reversible, orally active and selectivemonoamine oxidaseB (MAO-B)inhibitor with anIC₅₀of 0.02 nM.Monoamine OxidaseB inhibitor 1 has antioxidant and anti-neuroinflammatory activities.Monoamine OxidaseB inhibitor 1 can across the blood-brain barrier (BBB), and can be used for Parkinson’s disease study^[1].

In cellular experiments, Monoamine Oxidase B inhibitor 1 (compound 14a; 0.5-10.0 μM) could significantly decrease the production of NO and TNF-α in LPS-stimulated BV-2 cells^[1].

In in vivo acute and subacute MPTP-induced mice model of Parkinson’s disease, Monoamine Oxidase B inhibitor 1 (compound 14a; 6-37.4 mg/kg; oral administration) could significantly improve most behavioral disorders, restore the dopamine content and decrease the MDA content in the mice striatum^[1].

298.31

C₁₈H₁₅FO₃

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