Sulfisoxazole (Sulfafurazole) 是一种内皮素受体拮抗剂，对内皮素受体 A 和内皮素受体 B 的 IC50 值分别为 0.60 μM 和 22 μM。
| Cas No. | 127-69-5 |
| 别名 | 磺胺异恶唑; Sulfafurazole |
| 化学名 | 4-amino-N-(3,4-dimethyl-1,2-oxazol-5-yl)benzenesulfonamide |
| Canonical SMILES | CC1=C(ON=C1C)NS(=O)(=O)C2=CC=C(C=C2)N |
| 分子式 | C11H13N3O3S |
| 分子量 | 267.3 |
| 溶解度 | ≥ 10.65mg/mL in DMSO |
| 储存条件 | Store at -20°C |
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
| Shipping Condition | Evaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request |
| 产品描述 | Sulfisoxazole, an endothelin receptor antagonist, is a sulfonamide antibacterial with an oxazole substituent.Target: Antibacterial; Endothelin ReceptorThe sulfanilamide antibacterial agent sulfisoxazole was found to be a good endothelin receptor antagonist (IC50's of 0.60 microM and 22 microM for the ETA and ETB receptors, respectively) [1]. Sulfisoxazole is used to treat or prevent infections in many different parts of the body. It belongs to the group of medicines known as sulfonamide antibiotics. It works by preventing the growth of bacteria [2]. References:
[1]. Chan, M.F., et al., Identification of a new class of ETA selective endothelin antagonists by pharmacophore directed screening. Biochem Biophys Res Commun, 1994. 201(1): p. 228-34.
[2]. http://www.mayoclinic.org/drugs-supplements/sulfisoxazole-oral-route/description/drg-20072998 |
