AChE/BuChE/MAO-B-IN-1

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CAS NO:

2834758-29-9

AChE/BuChE/MAO-B-IN-1 是人乙酰胆碱酯酶 (hAChE)、丁酰胆碱酯酶 (hBuChE) 和单胺氧化酶-B (hMAO-B) 的抑制剂，IC₅₀分别为 4.8 μM、13.7 μM 和 1.11 μM。AChE/BuChE/MAO-B-IN-1 对 σ₁和 σ₂受体也表现出高亲和力，K_i分别为 42.8 nM 和 191 nM。AChE/BuChE/MAO-B-IN-1 可用于阿尔茨海默病的研究。

生物活性

AChE/BuChE/MAO-B-IN-1 (compound 19) is an inhibitor of human acetyl- (hAChE), butyrylcholinesterase (hBuChE) and monoamine oxidase-B (hMAO-B) withIC₅₀s of 4.8 μM, 13.7 μM, and 1.11 μM, respectively. AChE/BuChE/MAO-B-IN-1 also exhibits high affinity to both the σ₁and σ₂receptors with K_ivalues of 42.8 nM (human σ₁receptor) and 191 nM (rat σ₂receptor), respectively. AChE/BuChE/MAO-B-IN-1 can be used for Alzheimer’s disease research^[1].

IC₅₀& Target^[1]

hAChE

4.8 μM (IC₅₀)

hBCHE

13.7 μM (IC₅₀)

hMAO-B

1.11 μM (IC₅₀)

分子量

289.37

Formula

C₁₇H₂₃NO₃

CAS 号

2834758-29-9

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.