Ornidazole(Ro 7-0207) 是一种 5-硝基咪唑衍生物，对厌氧菌具有抗原生动物和抗菌特性。
| Cas No. | 16773-42-5 |
| 别名 | 奥硝唑; Ro 7-0207 |
| 化学名 | 1-chloro-3-(2-methyl-5-nitroimidazol-1-yl)propan-2-ol |
| Canonical SMILES | CC1=NC=C(N1CC(CCl)O)[N+](=O)[O-] |
| 分子式 | C7H10ClN3O3 |
| 分子量 | 219.63 |
| 溶解度 | ≥ 11mg/mL in DMSO |
| 储存条件 | 4°C, protect from light, stored under nitrogen |
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
| Shipping Condition | Evaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request |
| 产品描述 | Ornidazole(Ro 7-0207) is a 5-nitroimidazole derivative with antiprotozoal and antibacterial properties against anaerobic bacteria. Target: Antibacterial; AntiparasiticOrnidazole is a drug that cures some protozoan infections. Ornidazole 1 g/day is effective for the prevention of recurrence of Crohn's disease after ileocolonic resection [1]. Ornidazole is converted to reduction products that interact with DNA to cause destruction of helical DNA structure and strand leading to a protein synthesis inhibition and cell death in susceptible organisms [2]. References:
[1]. Rutgeerts, P., et al., Ornidazole for prophylaxis of postoperative Crohn's disease recurrence: a randomized, double-blind, placebo-controlled trial. Gastroenterology, 2005. 128(4): p. 856-61.
[2]. Goldstein, E.J., V.L. Sutter, and S.M. Finegold, Comparative susceptibilities of anaerobic bacteria to metronidazole, ornidazole, and SC-28538. Antimicrob Agents Chemother, 1978. 14(4): p. 609-13. |
