Closulon (L631529; MK401) 是一种口服活性的杀吸虫剂，可对抗小牛和绵羊的肝吸虫（肝吸虫和巨吸虫）感染。
| Cas No. | 60200-06-8 |
| 别名 | 氯舒隆; L631529; MK401 |
| 化学名 | 4-amino-6-(1,2,2-trichloroethenyl)benzene-1,3-disulfonamide |
| Canonical SMILES | C1=C(C(=CC(=C1N)S(=O)(=O)N)S(=O)(=O)N)C(=C(Cl)Cl)Cl |
| 分子式 | C8H8Cl3N3O4S2 |
| 分子量 | 380.66 |
| 溶解度 | ≥ 17.05mg/mL in DMSO |
| 储存条件 | Store at -20°C |
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
| Shipping Condition | Evaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request |
| 产品描述 | Clorsulon is used in the treatment of Fasciola hepatica infections in calves and sheep.Target: AntiparasiticClorsulon is a competitive inhibitor of both 3-phosphoglycorate and ATP and had a Ki of 0.29 mM, inhibits glucose utilization and acetate and propionate formation by mature Fasciola hepatica in vitro. [1] Clorsulon (a single dose of 15 mg/kg) is effective in removing over 90% of immature Fasciola hepatica from sheep (6 weeks after infection) and calves (8 weeks after infection). A 2.5 mg/kg dose removed over 90% of mature (16 weeks old) liver fluke from sheep [1]. Clorsulon causes severe disruption to the tegument and gut of Fasciola hepatica after in vivo incubation [2]. References:
[1]. Mrozik, H., et al., 4-amino-6-(trichloroethenyl)-1,3-benzenedisulfonamide, a new, potent fasciolicide. J Med Chem, 1977. 20(9): p. 1225-7.
[2]. Meaney, M., et al., Transmission electron microscope study of the ultrastructural changes induced in the tegument and gut of Fasciola hepatica following in vivo drug treatment with clorsulon. Parasitol Res, 2004. 92(3): p. 232-41. |
