MAO-B-IN-9 (compound 16) 是一种有效的、选择性的、透过血脑屏障的、不可逆的、时间依赖性的MAO-B(单胺氧化酶 B) 抑制剂,其IC50值为 0.18 μM。MAO-B-IN-9 可防止 Aβ1-42诱导的神经元细胞死亡。MAO-B-IN-9 具有神经保护作用,其机制可能与 Aβ1-42抗聚集作用有关。
生物活性 | MAO-B-IN-9 (compound 16) is a potent, selective, BBB-penetrated, irreversible and time-dependentMAO-B(monoamine oxidase B) inhibitor, with anIC50of 0.18 μM. MAO-B-IN-9 prevents Aβ1-42-induced neuronal cell death. MAO-B-IN-9 shows neuroprotective effects, which may be the result of its Aβ1-42anti-aggregation effects[1]. |
IC50& Target | MAO-B 0.178 ± 0. μM (IC50) |
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运输条件 | Room temperature in continental US; may vary elsewhere. |
储存方式 | Please store the product under the recommended conditions in the Certificate of Analysis. |