E1R

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E1R

本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。

CAS NO:

1301211-78-8

E1R 是一种sigma-1受体的正变构调节剂 (Sig1R PAM)，具有认知增强效果。

生物活性

E1R is a positive allosteric modulator ofsigma-1 receptors(Sig1R PAM) with cognition-enhancing activity^[1].

体外研究
(In Vitro)

The only target for E1R (inhibition or enhancement of radioligand binding exceeding 20%) is the sigma receptor. 10 μM E1R does not displace the radioligand, but instead increases the specific binding of a non-selective radioligand ([³H]1,3-di(2-tolyl)guanidine) for the sigma receptor by 38% in Jurkat cells^[1].

体内研究
(In Vivo)

E1R demonstrates efficacy against scopolamine-induced cholinergic dysfunction in mice. Treatment with E1R (0.1-10 mg/kg; administered i.p. 60 min before the training session) significantly improves cognitive function in a dose-related manner in mice^[1].

Animal Model:	Male ICR and Balb/c mice weighed 23-25 g^[1]
Dosage:	0.1, 1 and 10 mg/kg
Administration:	Administered i.p. 60 min before the training session
Result:	Treatment at doses of 1 and 10 mg/kg increased retention latency by 194 and 211%, respectively, compared with the control group.

分子量

232.28

性状

Solid

Formula

C₁₃H₁₆N₂O₂

CAS 号

1301211-78-8

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

溶解性数据

In Vitro:

DMSO : 60 mg/mL(258.31 mM;Need ultrasonic)

配制储备液

浓度溶剂体积质量

1 mg

5 mg

10 mg

1 mM	4.3051 mL	21.5257 mL	43.0515 mL
5 mM	0.8610 mL	4.3051 mL	8.6103 mL
10 mM	0.4305 mL	2.1526 mL	4.3051 mL

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80℃, 6 months; -20℃, 1 month。-80℃ 储存时，请在 6 个月内使用，-20℃ 储存时，请在 1 个月内使用。