Amitriptyline-d6 hydrochloride

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CAS NO:

203645-63-0

盐酸阿米替林 d6 (盐酸盐)

Amitriptyline-d6 hydrochloride 是 Amitriptyline hydrochloride 的氘代物。Amitriptyline hydrochloride 是一种血清素再摄取转运体 (SERT) 和去甲肾上腺素再摄取转运体 (NET) 抑制剂，对人的 SERT 和 NET 作用的K_i值分别为 3.45 nM 和 13.3 nM。Amitriptyline hydrochloride 还与多巴胺再摄取转运体 (DAT) 结合，其K_i为 2.58 μM。Amitriptyline hydrochloride 也抑制肾上腺素能受体 (adrenergic receptor)、毒蕈碱受体 (muscarinic receptor)、组胺受体 (histamine receptor)、5-羟色胺受体 (5-HT receptor)。Amitriptyline hydrochloride 是一种具有强神经营养活性的TrkA和TrkA受体激动剂。Amitriptyline hydrochloride 具有抗抑郁作用。

生物活性	Amitriptyline-d6 hydrochloride is the deuterium labeled Amitriptyline hydrochloride. Amitriptyline hydrochloride is an inhibitor ofserotonin reuptake transporter (SERT)andnoradrenaline reuptake transporter (NET), withK_is of 3.45 nM and 13.3 nM for human SERT and NET, respectively. Amitriptyline hydrochloride also weakly binds todopamine reuptake transporter (DAT)with aK_iof 2.58 μM. Amitriptyline hydrochloride also inhibitsadrenergic,muscarinic,histamineand5-HT receptors. Amitriptyline hydrochloride is aTrkAandTrkBreceptors agonist with potent neurotrophic activity. Amitriptyline hydrochloride has antidepressant activity^[1]^[2]^[3].
体外研究 (In Vitro)	Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs^[1].
分子量	319.90
Formula	C₂₀H₁₈D₆ClN
CAS 号	203645-63-0
中文名称	盐酸阿米替林 d6 (盐酸盐)
运输条件	Room temperature in continental US; may vary elsewhere.
储存方式	Please store the product under the recommended conditions in the Certificate of Analysis.