Anticancer agent 76 (Compound CT2-3) 是一种抗癌剂。Anticancer agent 76 能显著抑制人 NSCLC 细胞增殖，诱导细胞周期阻滞、ROS生成和细胞凋亡（apoptosis）。
| 生物活性 | Anticancer agent 76 (Compound CT2-3) is an anticancer agent. Anticancer agent 76 significantly inhibits the proliferation of human NSCLC cells, induces cell cycle arrest, causesROSgeneration and induces cellapoptosis[1]. |
体外研究
(In Vitro) | Anticancer agent 76 (Compound CT2-3) (0-80 μM, 24 h) inhibits the proliferation of human NSCLC cells[1].
Anticancer agent 76 (40 μM, 24 h) arrests cell cycle at G1 phase, induces apoptosis and ROS, suppresses the expression of c-Myc and topoisomerases in NSCLC cells[1].
Cell Proliferation Assay[1] | Cell Line: | A549 and H460 | | Concentration: | 0, 10, 20, 40, 60 and 80 μM | | Incubation Time: | 24 h | | Result: | Inhibited the proliferation with IC50values of 41.63 μM and 38.03 μM against A549 and H460 cells, respectively. |
Cell Cycle Analysis[1] | Cell Line: | H460 | | Concentration: | 40 μM | | Incubation Time: | 24 h | | Result: | Resulted in increasing cell populations at the G1 phase, down-regulated CDK4, CDK6 and cyclin D1. |
Apoptosis Analysis[1] | Cell Line: | A549 and H460 | | Concentration: | 20 μM and 40 μM | | Incubation Time: | 24 h | | Result: | Induced apoptosis. |
Western Blot Analysis[1] | Cell Line: | H460 cell | | Concentration: | 40 μM | | Incubation Time: | 24 h | | Result: | Down-regulated mRNA of TOP2B, TOP3B and c-Myc. |
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| 运输条件 | Room temperature in continental US; may vary elsewhere. |
| 储存方式 | Please store the product under the recommended conditions in the Certificate of Analysis. |
