hVEGF-IN-2

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hVEGF-IN-2

本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。

CAS NO:

186610-88-8

hVEGF-IN-2 (compound 19) 是选择性的VEGF(Flk-1) 受体酪氨酸激酶抑制剂，IC₅₀值为 2.5 μM。hVEGF-IN-2 抑制 PDGF 受体酪氨酸激酶活性，IC₅₀值为 33.1 μM。hVEGF-IN-2 可用于开发受体酪氨酸激酶特异性药物。

生物活性

hVEGF-IN-2 (compound 19) is a selectiveVEGF(Flk-1)receptor tyrosine kinases(RTK) inhibitor with anIC₅₀value of 2.5 μM. hVEGF-IN-2 inhibitsPDGFRTK activity with anIC₅₀value of 33.1 μM. hVEGF-IN-2 can be used for the development of RTK-specific drugs^[1].

IC₅₀& Target

VEGFR1

2.5 μM (IC₅₀)

PDGF

33.1 μM (IC₅₀)

体外研究
(In Vitro)

hVEGF-IN-2 (0-100 μM) shows the inhibitory activities to particular RTKs at the cellular level with IC₅₀values of 2.5, 33.1, ＞100, ＞100 and ＞100 nM for VEGF, PDGF, EGF, HER-2 and IGF-1, respectively^[1].

分子量

306.36

Formula

C₁₉H₁₈N₂O₂

CAS 号

186610-88-8

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.