VEGFR-2-IN-30 是一种 VEGFR-2 抑制剂 (IC50: 66 nM)。VEGFR-2-IN-30 还抑制 PDGFR、EGFR 和 FGFR1，IC50s 分别为 180、98、82 nM。VEGFR-2-IN-30 将癌细胞阻滞在 S 期并诱导早期和晚期细胞凋亡 (apoptosis)。
| 生物活性 | VEGFR-2-IN-30 is aVEGFR-2inhibitor (IC50: 66 nM). VEGFR-2-IN-30 also inhibitsPDGFR,EGFRandFGFR1withIC50s of 180, 98, 82 nM respectively. VEGFR-2-IN-30 arrestscancercell at S-phase and induces early and lateapoptosis[1]. |
| IC50& Target[1] | |
体外研究
(In Vitro) | VEGFR-2-IN-30 (化合物 8f) (10 μM) 抑制 35% 的 UO-31 细胞生长[1]。
VEGFR-2-IN-30 (10 μg/mL, 72 h) 抑制 HUVEC 细胞迁移[1].
VEGFR-2-IN-30 (5.29 μM, 24 h) 在阻滞 UO-31 细胞 在S 期[1]。
VEGFR-2-IN-30 (5.29 μM, 24 h) 诱导 UO-31 细胞凋亡[1]。
VEGFR-2-IN-30 (5.29 μM, 24 h) 在 UO-31 细胞中增加 Bax 水平并下调 Bcl-2 水平[1]。
Cell Migration Assay[1] | Cell Line: | NHUVEC | | Concentration: | 10 μg/mL | | Incubation Time: | 72 h | | Result: | Inhibited cell migration by 58.52%. |
Apoptosis Analysis[1] | Cell Line: | UO-31 cell | | Concentration: | 5.29 μM | | Incubation Time: | 24 h | | Result: | Increased early apoptotic cells from 0.61% to 23.51% and late apoptotic cells from 0.13% to 9.28%.
Increased the level of active caspase-3. |
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| 运输条件 | Room temperature in continental US; may vary elsewhere. |
| 储存方式 | Please store the product under the recommended conditions in the Certificate of Analysis. |
