AAL993

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AAL993

本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。

CAS NO:

269390-77-4

AAL993 是一种有效的、选择性的、具有口服活性的VEGFR抑制剂，对 VEGFR1、VEGFR2 和 VEGFR3 的IC₅₀分别为 130 nM、23 nM 和 18 nM。AAL993 对其他酪氨酸激酶的抑制作用较弱。AAL993 具有有效的抗血管生成和抗肿瘤特性。

生物活性

IC₅₀s of 130 nM, 23 nM, and 18 nM for VEGFR1, VEGFR2, and VEGFR3, respectively. AAL993 shows less potently inhibits other tyrosine kinases. AAL993 possesses potent antiangiogenic and antitumor properties^[1].

IC₅₀& Target^[1]

VEGFR1

130 nM (IC₅₀)

VEGFR2

23 nM (IC₅₀)

VEGFR3

18 nM (IC₅₀)

体外研究
(In Vitro)

AAL993 suppresses HIF-1α expression through ERK inhibition without affecting Akt phosphorylation^[2].

体内研究
(In Vivo)

AAL993 (compound 5) potently inhibits VEGF-induced angiogenesis in an implant model, with an ED₅₀value of 7 mg/kg^[1].
In B16 melanoma xenograft model, AAL993 (24-100 mg/kg; p.o.; daily; for 14days) inhibits both the growth of the primary tumor as well as the formation of spontaneous peripheral metastases^[1].

分子量

371.36

Formula

C₂₀H₁₆F₃N₃O

CAS 号

269390-77-4

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.