VEGFR-2-IN-28

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VEGFR-2-IN-28

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CAS NO:

2447597-39-7

VEGFR-2-IN-28 (compound 12c) 是一种有效的 VEGFR-2 抑制剂，其IC₅₀值为 0.83 μM。VEGFR-2-IN-28诱导细胞凋亡 (apoptosis)，具有抗肿瘤活性。

生物活性

VEGFR-2-IN-28 (compound 12c) is a potentVEGFR-2inhibitor withIC₅₀value of 0.83 μM. VEGFR-2-IN-28 inducesapoptosisand has anticancer activity^[1].

IC₅₀& Target^[1]

VEGFR-2

0.83 μM (IC₅₀)

体外研究
(In Vitro)

VEGFR-2-IN-28 (compound 12c) (24 hours; MCF-7 cells) has anticancer activity withIC₅₀value of 16.50 μM^[1].
VEGFR-2-IN-28 (compound 12c) (24 hours; MCF-7 cells) prompts pre-G1 apoptosis, cell growth cessation at G2/M phase and induces apoptosis via activation of caspase-3^[1].

Apoptosis Analysis^[1]

Cell Line:	MCF-7 cells
Concentration:	16.50 μM
Incubation Time:	24 hours
Result:	Induced apoptotic cells resulting in apoptosis percentage 28.41 %.

Cell Cycle Analysis^[1]

Cell Line:	MCF-7 cells
Concentration:	16.50 μM
Incubation Time:	24 hours
Result:	Increased in the percentage of cells at pre-G1 phase and at G2/M phase to 28.41% and 46.05%, respectively.

Immunofluorescence^[1]

Cell Line:	MCF-7 cells
Concentration:	16.50 μM
Incubation Time:	24 hours
Result:	Increased in the level of caspase-3.

分子量

539.46

Formula

C₂₆H₁₇N₇O₇

CAS 号

2447597-39-7

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.