Paeonoside 是一种在P. suffruticosa中鉴定的生物活性化合物，可以促进成骨细胞分化中的伤口愈合和迁移。Paeonoside 也被报道具有一定的抗糖尿病活性，可防止脓毒症引起的致死性。
| 生物活性 | Paeonoside is a bioactive compound identified inP. suffruticosathat promotes wound healing and migration in osteoblast differentiation. Paeonoside has also been reported to have some antidiabetic activity and may prevent sepsis-induced lethality[1]. |
体外研究
(In Vitro) | Paeonoside (PASI) (0.1-100 μM, 24 h) has no cytotoxic effect on pro-osteoblasts of MC3T3-E1 cells[1].
Paeonoside (PASI) (1-30 μM, 24 h) can significantly restore wound areas and promote cell migration in a dose-dependent manner during the induction of preosteoblast of MC3T3-E1 cells differentiation using osteogenic supplement (OS) medium. In parallel, PASI promotes alkaline phosphatase (ALP) staining and its activity in a dose-dependent manner[1].
Western Blot Analysis[1] | Cell Line: | Pro-osteoblasts of MC3T3-E1 cells | | Concentration: | 1-10 μM | | Incubation Time: | 24 h | | Result: | Increased the expression of BMP2 and Wnt3a, stimulated Smad1/5/8 phosphorylation, GSK3β phosphorylation and β-linked protein expression as well as upregulated RUNX2 expression. |
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| 来源 | - Plants
- Ranunculaceae
- Delphinium staphisagriaL.
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| 运输条件 | Room temperature in continental US; may vary elsewhere. |
| 储存方式 | Please store the product under the recommended conditions in the Certificate of Analysis. |
