H-151是一种高效、选择性、共价的STING拮抗剂，能够降低TBK1的磷酸化，抑制人STING的棕榈酰化。
| Cas No. | 941987-60-6 |
| Canonical SMILES | O=C(NC1=CNC2=C1C=CC=C2)NC3=CC=C(CC)C=C3 |
| 分子式 | C17H17N3O |
| 分子量 | 279.34 |
| 溶解度 | DMSO : 125 mg/mL (447.48 mM);Water :< 0.1 mg/mL (insoluble) |
| 储存条件 | Store at -20°C |
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
| Shipping Condition | Evaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request |
| 产品描述 | H-151 is a highly potent, selective and covalent antagonist of STING, reduces TBK1 phosphorylation and suppresses human STING palmitoylation[1].
STING[1] [1]. Haag SM, et al. Targeting STING with covalent small-molecule inhibitors. Nature. 2018 Jul;559(7713):269-273. |
