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ChX710
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
ChX710图片
包装与价格:
包装价格(元)
10mM (in 1mL DMSO)询价
5mg询价
10mg询价
25mg询价
50mg询价
100mg询价

ChX710可以启动I型干扰素对胞质DNA的反应,诱导ISRE启动子序列、特异性细胞干扰素刺激基因(ISGs)和干扰素调节因子(IRF)3的磷酸化。
Canonical SMILESO=C(NC(C)CN(C)C)C1=C(N=C(C2=CC=NC=C2)N3)C3=CC=C1
分子式C18H21N5O
分子量323.39
溶解度DMSO : 20 mg/mL (61.84 mM)
储存条件Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

ChX710 could prime the type I interferon response to cytosolic DNA, which induces the ISRE promoter sequence, specific cellular Interferon-Stimulated Genes (ISGs), and the phosphorylation of Interferon Regulatory Factor (IRF) 3.

ChX710 treatment is found to efficiently prime the cellular response to DNA transfection via STING as assessed by strong synergistic effects on IFN-β expression at both transcriptional and protein levels [1].

[1]. Khiar S, et al. Identification of a small molecule that primes the type I interferon response to cytosolic DNA. Sci Rep. 2017 May 31;7(1):2561.

 
 
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