盐酸异丙嗪是第一代抗组胺药； H1 受体的强拮抗剂和中度 mACh 受体拮抗剂，对 5-HT2A、5-HT2C、D2 和 α；1-肾上腺素能受体具有中等亲和力。
| Cas No. | 58-33-3 |
| 别名 | 盐酸异丙嗪 |
| 化学名 | N,N-dimethyl-1-(10H-phenothiazin-10-yl)propan-2-amine hydrochloride |
| Canonical SMILES | CC(N(C)C)CN1C2=CC=CC=C2SC3=CC=CC=C31.Cl |
| 分子式 | C17H21ClN2S |
| 分子量 | 320.88 |
| 溶解度 | ≥ 14.2mg/mL in DMSO |
| 储存条件 | 4°C, protect from light ,unstable in solution, ready to use. |
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
| Shipping Condition | Evaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request |
| 产品描述 | Promethazine hydrochloride is the first-generation antihistamine; strong antagonist of the H1 receptor and moderate mACh receptor antagonist, moderate affinity for 5-HT2A, 5-HT2C, D2 and α1-adrenergic receptors. References:
[1]. Strenkoski-Nix LC, et al. Pharmacokinetics of promethazine hydrochloride after administration of rectal suppositories and oral syrup to healthy subjects. Am J Health Syst Pharm. 2000 Aug 15;57(16):1499-505.
[2]. Fiorella D, et al. The role of the 5-HT2A and 5-HT2C receptors in the stimulus effects of hallucinogenic drugs. I: Antagonist correlation analysis. Psychopharmacology (Berl). 1995 Oct;121(3):347-56.
[3]. Seeman P, et al. Dopamine D2 receptor binding sites for agonists. A tetrahedral model. Mol Pharmacol. 1985 Nov;28(5):391-9.
[4]. Burt DR, et al. Antischizophrenic drugs: chronic treatment elevates dopamine receptor binding in brain. Science. 1977 Apr 15;196(4287):326-8. |
