Quassin

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Quassin

本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。

CAS NO:

76-78-8

Nigakilactone D

Quassin (Nigakilactone D) 是一种从Quassia amara的茎皮提取物中提取的生物活性三萜。Quassin 抑制P. falciparum，IC₅₀为 0.15 μM。Quassin 具有可逆的避育能力，抗雌激素和抗疟原虫活性。

生物活性

Quassin (Nigakilactone D) is a bioactive triterpenoid from stem bark extract ofQuassia amara. Quassin inhibitsP. falciparumwith anIC₅₀of 0.15 μM. Quassin possesses reversible antifertility, anti-estrogenic and anti-plasmodial activity^[1]^[2].

IC₅₀& Target

IC50: 0.15 μM (P. falciparum)^[2]

体外研究
(In Vitro)

Quassin (Compound 1; 5-25 ng/mL) inhibits both the basal and luteinizing hormone-stimulated testosterone secretion of rat Leydig cells in a dose-dependent fashion^[3].

体内研究
(In Vivo)

Quassin (0.1-2.0 mg/kg; oral administration; daily; for 60 days; females albino rats) treatment shows a significant decrease in the weight of the ovary and uterus. And also shows a significant decrease in serum estrogen levels in quassin treated rats. The Quassin treated rats has a significantly decreased mean litter number and weight. Quassin does not adversely affect the weight of the kidney, heart, liver and the body of the rats^[1].

Animal Model:	35 females albino rats (150-170 g)^[1]
Dosage:	0.1 mg/kg, 1.0 mg/kg and 2.0 mg/kg
Administration:	Oral administration; daily; for 60 days
Result:	There was a significant decrease in the weight of the ovary and uterus in all the groups relative to the control. There was also a significant decrease in serum estrogen levels in quassin treated rats.

分子量

388.45

性状

Solid

Formula

C₂₂H₂₈O₆

CAS 号

76-78-8

中文名称

苦楝树甙,苦木素

结构分类

Terpenoids
Triterpenes

来源

Plants
Simaroubaceae
Picrasma quassioides(D．Don)Benn．

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)