Ligustroside

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Ligustroside

本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。

CAS NO:

35897-92-8

Ligstroside

Ligustroside (Ligstroside) 是一种 secoiridoid 衍生物，在早期阿尔茨海默病 (AD) 和脑老化模型中的线粒体生物能量学方面表现出色，其机制可能不会干扰 Aβ 的产生。Ligustroside 显着抑制脂多糖激活的 RAW264.7 巨噬细胞中一氧化氮的产生。

生物活性

Ligustroside (Ligstroside), a secoiridoid derivative, has outstanding performance on mitochondrial bioenergetics in models of early Alzheimer's disease (AD) and brain ageing by mechanisms that may not interfere with Aβ production. Ligustroside significantly inhibits nitric oxide production in lipopolysaccharide-activated RAW264.7 macrophages^[1]^[2].

体外研究
(In Vitro)

Ligstroside increases mRNA expression of SIRT1, CREB1, complex I, and GPx1 in SH-SY5Y-APP₆₉₅cells^[1].

体内研究
(In Vivo)

Ligstroside (50 mg/kg; a supplemented diet for 6 months) protects against mitochondrial dysfunction in models of early Alzheimer's disease and brain ageing^[1].

Animal Model:	Female NMRI mice, aged 12 months^[1]
Dosage:	50 mg/kg
Administration:	Received a supplemented diet for 6 months (equivalent to 6.25 mg/kg b.w.)
Result:	Showed improved spatial working memory; Restored brain ATP levels in aged mice and led to a significant life extension compared to aged control animals.

分子量

524.51

性状

Solid

Formula

C₂₅H₃₂O₁₂

CAS 号

35897-92-8

结构分类

Terpenoids
Iridoids

Phenols
Monophenols

来源

Plants
Oleaceae
Ligustrum japonicumThunb.

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

4°C, sealed storage, away from moisture and light

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)