Lasiocarpine, ahepatotoxic pyrrolizidine alkaloid (PA), causes fatal liver veno-occlusive diseasein vivo. Lasiocarpine is toxic only after its metabolic conversion to the toxic intermediate, including dehydrolasiocarpine and N-oxide^[1].

Lasiocarpine is toxic only after its metabolic conversion to the toxic intermediate, known as dehydrolasiocarpine^[1].
Dehydrolasiocarpine and other putative didehydropyrrolizidine alkaloids (the pyrrolic esters) are very reactive,they attack nucleophilic macromolecules such as DNA and proteins, eliciting severe toxicities, including liver veno-occlusive disease and tumors^[1].
Lasiocarpine is mainly metabolized in vitro through five metabolic pathways, dehydrogenation, ester bond cleavage, demethylation^[1].

411.49

C₂₁H₃₃NO₇

303-34-4

• Alkaloids
• Pyrrole Alkaloids

• Plants
• Boraginaceae
• Heliotropium europaeumL.

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.