Platyconic acid A

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Platyconic acid A

本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。

CAS NO:

68051-23-0

Platyconic Acid A 是桔梗皂苷的活性成分，可用于减轻气道炎症的研究。

生物活性

Platyconic Acid A is an active component of changkil saponins fromplatycodon grandiflorumand can be used for the research of reducing airway inflammation^[1].

体外研究
(In Vitro)

Platyconic Acid A (0.5~2 μM; 30 minutes; A549 cells) inhibits PMA-induced NF-κB p65 phosphorylation, IκBα phosphorylation and degradation and Akt phosphorylation in a concentration-dependent manner^[1].
Platyconic Acid A (0.5~2 μM; 24 hours; A549 cells) decreases PMA-increased MUC5AC mRNA expression in a concentration-dependent manner^[1].

Western Blot Analysis^[1]

Cell Line:	A549 cells
Concentration:	0.5~2 μM
Incubation Time:	30 minutes
Result:	Inhibited PMA-induced NF-κB p65 phosphorylation, IκBα phosphorylation and degradation and Akt phosphorylation in a concentration-dependent manner.

RT-PCR^[1]

Cell Line:	A549 cells
Concentration:	0.5~2 μM
Incubation Time:	24 hours
Result:	Decreased PMA-increased MUC5AC mRNA expression in a concentration-dependent manner.

分子量

1239.31

性状

Solid

Formula

C₅₇H₉₀O₂₉

CAS 号

68051-23-0

结构分类

Terpenoids
Triterpenes

来源

Plants
Campanulaceae
Platycodon grandiflorus(Jacq.) A. DC.

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

溶解性数据

In Vitro:

H₂O : 25 mg/mL(20.17 mM;Need ultrasonic)

配制储备液

浓度溶剂体积质量

1 mg

5 mg

10 mg

1 mM	0.8069 mL	4.0345 mL	8.0690 mL
5 mM	0.1614 mL	0.8069 mL	1.6138 mL
10 mM	0.0807 mL	0.4035 mL	0.8069 mL

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80℃, 6 months; -20℃, 1 month (protect from light)。-80℃ 储存时，请在 6 个月内使用，-20℃ 储存时，请在 1 个月内使用。