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13(S)-HODE
本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。
13(S)-HODE图片
CAS NO:29623-28-7
包装与价格：
包装价格(元)
25µg询价
50µg询价
100µg询价
250µg询价

13(S)-HODE(13(S)-HODE)是亚油酸15-脂氧合酶(15-LOX)代谢的产物，作为内源性配体激活PPARγ；。
Cas No.29623-28-7
别名13(S)-HODE
化学名13S-hydroxy-9Z,11E-octadecadienoic acid
Canonical SMILESCCCCC[C@H](O)/C=C/C=C\CCCCCCCC(O)=O
分子式C18H32O3
分子量296.5
溶解度DMF: >50 mg/ml (per Rao Maddipati),DMSO: >50 mg/ml (per Rao Maddipati),Ethanol: >50 mg/ml (per Rao Maddipati),PBS pH 7.2: 1 mg/ml
储存条件Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

13(S)-HODE is produced by incubation of linoleic acid with plant and mammalian lipoxygenases. It has been shown to inhibit the adhesion of tumor cells to the endothelium at concentrations around 1 μM,[1],[2] and down regulates the expression of the IRGpIIb/IIIa receptor.[3]

Reference:

[1]. Buchanan, M.R., Haas, T.A., Lagarde, M., et al. 13-Hydroxyoctadecadienoic acid is the vessel wall chemorepellant factor, LOX The Journal of Biological Chemisty 260, 16056-16059 (1985).
[2]. Honn, K.V., Nelson, K.K., Renaud, C., et al. Fatty acid modulation of tumor cell adhesion to microvessel endothelium and experimental metastasis Prostaglandins 44(5), 413-429 (1992).
[3]. Grossi, I.M., Fitzgerald, L.A., Umbarger, L.A., et al. Bidirectional control of membrane expression and/or activation of the tumor cell IRGpIIb/IIIa receptor and tumor cell adhesion by lipoxygenase products of arachidonic acid and linoleic acid Cancer Res. 49(4), 1029-1037 (1989).

 
 
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