Gitogenin is a natural steroid isolated from the whole plant ofTribulus longipetalus. Gitogenin is a selective inhibitor ofUDP-glucuronosyltransferase 1A4 (UGT1A4)and enzymeα-glucosidasewithIC₅₀values of 0.69 μM (use trifluoperazine as a substrate) and 37.2 μM, respectively, and does not inhibit the activities of major humancytochrome P450isoforms^[1][2].

IC50: 0.69 μM (UDP-glucuronosyltransferase 1A4)^[1]; IC50: 37.2 μM (α-glucosidase)^[2]

When tamoxifen is used as the substrate metabolized by UGT1A4 in HLMs, Gitogenin exhibits potent inhibition of tamoxifen, with anIC₅₀value of 6.13 μM. Similarly, for midazolam as the substrate of UGT1A4, theIC₅₀value is 5.7 μM. In addition, when olanzapine is used as a substrate of UGT1A4, theIC₅₀value is determined as 6.0 μM. Finally, we also evaluats Gitogenin for asenapine glucuronidation mediated by UGT1A4, and similar inhibition effect is observed, with anIC₅₀value of 22.0 μM^[1].

Stimulation of growth hormone release is investigated on rat pituitary cells in vitro. Gitogenin (20 μg/mL) shows rat growth-hormone (rGH) release stimulating activities (26.1 ng/mL)^[3].

432.64

Solid

C₂₇H₄₄O₄

511-96-6

• Steroids

• Plants
• Zygophyllaceae
• Tribulus terresterLinn.

Room temperature in continental US; may vary elsewhere.

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

DMSO : 1.85 mg/mL(4.28 mM;ultrasonic and warming and heat to 60℃)

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80℃, 6 months; -20℃, 1 month (protect from light)。-80℃ 储存时，请在 6 个月内使用，-20℃ 储存时，请在 1 个月内使用。