Sulfuretin

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Sulfuretin

本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。

CAS NO:

120-05-8

硫黄菊素

Sulfuretin 通过抑制NF-κB通路来抑制炎症反应。 Sulfuretin 可用于过敏性气道炎症的研究。Sulfuretin 减少氧化应激、血小板聚集和诱变。Sulfuretin 是一种竞争性的有效单酚酶和二酚酶活性抑制剂，IC₅₀为 13.64 μM。

生物活性

Sulfuretin inhibits the inflammatory response by suppressing theNF-κBpathway. Sulfuretin can be used for the research of allergic airway inflammation. Sulfuretin reduces oxidative stress, platelet aggregation, and mutagenesis^[1]. Sulfuretin is a competitive and potent inhibitor of monophenolase and diphenolase activities with the IC₅₀of 13.64 μM^[2].

体外研究
(In Vitro)

Sulfuretin is one of the main flavonoids produced byRhus verniciflua. Sulfuretin efficiently inhibits the infiltration of inflammatory cells and attenuates allergic airway inflammation.

体内研究
(In Vivo)

Sulfuretin inhibits the inflammatory responses by suppressing the NF-κB pathway in type 1 diabetes models. Sulfuretin (40 μg/kg; single intraperitoneal injection 2 h after the last OVA challenge) suppresses ovalbumin (OVA)-induced chemotaxis and airway inflammation^[1].

Animal Model:	Pathogen-free male BALB/c mice (7-8 weeks old)^[1]
Dosage:	40 μg/kg
Administration:	A single intraperitoneal injection was administered 2 h after the last OVA challenge
Result:	Suppressed OVA-induced chemotaxis and airway inflammation.

分子量

270.24

性状

Solid

Formula

C₁₅H₁₀O₅

CAS 号

120-05-8

中文名称

硫黄菊素

结构分类

Phenols
Polyphenols

来源

Plants
Anacardiaceae
Toxicodendron vernicifluum(Stokes) F. A. Barkl.

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

-20°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)