Hecogenin

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Hecogenin

本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。

CAS NO:

467-55-0

Hecogenin 是从剑麻 (Agave sisalana) 分离的类固醇皂苷，是人 UDP-葡萄糖醛酸糖基转移酶的选择性抑制剂。Hecogenin 具有广泛的药理活性，包括抗炎，抗真菌和胃保护作用。

生物活性

Hecogenin is a steroid saponin isolated fromAgave sisalanaand is a selective inhibitor ofhuman UDP-glucuronosyltransferases. Hecogenin has a wide spectrum of pharmacological activities, including anti-inflammatory, antifungal and gastroprotective effects^[1].

IC₅₀& Target

Human UDP-glucuronosyltransferases^[1]

体内研究
(In Vivo)

Hecogenin (3.1-90 mg/kg; oral administration; for 15 hours; male Swiss mice) acutely administered, before ethanol, exhibits a potent gastroprotective effect. The Hecogenin pretreatment normalizes GSH levels and significantly reduces lipid peroxidation and nitrite levels in the stomach, as evaluated by the ethanol-induced gastric lesion model. Hecogenin also decreases MPO release and significantly protects the gastric mucosa^[1].

Animal Model:	Male Swiss mice (20-30 g) with ethanol^[1]
Dosage:	3.1 mg/kg, 7.5 mg/kg, 15 mg/kg, 30 mg/kg, 60 mg/kg and 90 mg/kg
Administration:	Oral administration; for 15 hours
Result:	Normalized GSH levels and significantly reduced lipid peroxidation and nitrite levels in the stomach, as evaluated by the ethanol-induced gastric lesion model. Decreased MPO release and significantly protected the gastric mucosa.

分子量

430.62

性状

Solid

Formula

C₂₇H₄₂O₄

CAS 号

467-55-0

结构分类

Steroids

来源

Plants
Agavaceae
Agave sisalanaPerr. ex Engelm.

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

溶解性数据

In Vitro:

DMF : 16.67 mg/mL(38.71 mM;ultrasonic and warming and heat to 60℃)

DMSO :< 1 mg/mL (ultrasonic;warming;heat to 60℃)(insoluble or slightly soluble)

H₂O :< 0.1 mg/mL (ultrasonic;warming;heat to 60℃)(insoluble)

配制储备液

浓度溶剂体积质量

1 mg

5 mg

10 mg

1 mM	2.3222 mL	11.6112 mL	23.2223 mL
5 mM	0.4644 mL	2.3222 mL	4.6445 mL
10 mM	0.2322 mL	1.1611 mL	2.3222 mL

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80℃, 6 months; -20℃, 1 month。-80℃ 储存时，请在 6 个月内使用，-20℃ 储存时，请在 1 个月内使用。