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Meropenem trihydrate
本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。
Meropenem trihydrate图片
CAS NO:119478-56-7
包装与价格：
包装价格(元)
10mM (in 1mL DMSO)询价
25mg询价
50mg询价
100mg询价
250mg询价

Meropenem trihydrate (SM 7338 trihydrate) 是一种碳青霉烯类抗生素，具有广谱抗菌活性。
Cas No.119478-56-7
别名美罗培南三水合物; SM 7338 trihydrate
化学名(4R,5S,6S)-3-[(3S,5S)-5-(dimethylcarbamoyl)pyrrolidin-3-yl]sulfanyl-6-[(1R)-1-hydroxyethyl]-4-methyl-7-oxo-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylic acid;trihydrate
Canonical SMILESCC1C2C(C(=O)N2C(=C1SC3CC(NC3)C(=O)N(C)C)C(=O)O)C(C)O.O.O.O
分子式C17H31N3O8S
分子量437.51
溶解度≥ 20.7mg/mL in Water with gentle warming
储存条件Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

Meropenem trihydrate (SM-7338) is an active ingredient carbapenem antibiotic [1].

Meropenem trihydrate has shown the potent effect against gram-negative organisms with the MIC90 values of 0.03μM, 0.06μM, 0.06μM, 0.12μM,0.25μM, 0.12μM, 0.06μM, 0.12μM and 0.25μM for Escherichia coli (30), Klebsiella pneumonia(29), Klebsiella oxytoca (20), Enterobacter aerogenes (14), Enterobacter cloacae (29), Citrobacter freundii (20), Citrobacter diversus (12), proteus mirabilis (15) and Morganella morganii (15), respectively. In addition, Meropenem trihydrate has also been revealed to restrain gram-positive and anaerobic organisms with the MIC90 values of 0.008μM, 4μM and 0.015μM for Streptococcus pyogenes (20), Viridans group streptococci (27), Streptococcus pneumonia (15), respectively. Furthermore, Meropenem trihydrate has shown the different effect of pH on MIC, for example, the mean MIC values of 0.06μM and 0.03μM in pH5.5 and pH7.5, respectively [1].

References:
[1] Neu HC1, Novelli A, Chin NX.In vitro activity and beta-lactamase stability of a new carbapenem, SM-7338.Antimicrob Agents Chemother. 1989 Jul; 33(7):1009-18.

 
 
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