3,4,5-Tricaffeoylquinic acid

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本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。

CAS NO:

86632-03-3

3,4,5-triCQA

3,4,5-Tricaffeoylquinic acid (3,4,5-triCQA) 通过抑制 Akt 和 NF-κB 途径抑制肿瘤坏死因子-α 刺激角质形成细胞中炎性介质的产生。3,4,5-Tricaffeoylquinic acid 诱导人神经干细胞 G0/G1 细胞周期阻滞、肌动蛋白骨架组织、染色质重塑、神经元分化和骨形态发生蛋白信号传导。3,4,5-Tricaffeoylquinic acid 在衰老相关疾病的研究中具有潜在的应用前景。

生物活性

3,4,5-Tricaffeoylquinic acid (3,4,5-triCQA) inhibits tumor necrosis factor-α-stimulated production of inflammatory mediators in keratinocytes via suppression of Akt- and NF-κB-pathways. 3,4,5-Tricaffeoylquinic acid induces cell cycle arrest at G0/G1, actincytoskeletonorganization, chromatin remodeling, neuronal differentiation, andbone morphogenetic proteinsignaling in human neural stem cells. 3,4,5-Tricaffeoylquinic acid has the potential for the research of aging-associated diseases^[1]^[2].

体外研究
(In Vitro)

3,4,5-Tricaffeoylquinic acid (0-50 μM) reduces TNF-α-induced production of cytokines in HEK001 keratinocytes^[1].
3,4,5-Tricaffeoylquinic acid (15 μM, 35 min) inhibits TNF-α-induced IkBα phosphorylation and activation of NF-κB^[1].

Cell Viability Assay^[1]

Cell Line:	Keratinocytes
Concentration:	15, 25 and 50 μM
Incubation Time:	24 hours
Result:	Cell death was cell ~4-5% at 15 and 25 μM, ~9% at 50 μM.

Western Blot Analysis^[1]

Cell Line:	Keratinocytes
Concentration:	15 μM
Incubation Time:	20 min before 10 ng/mL TNF-α addition for 15 min
Result:	Decreased TNF-α-induced-IkBα phosphorylation of IkBα and levels of cytosolic NF-Κb p65, cytosolic NF-Κb p65.

分子量

678.59

性状

Solid

Formula

C₃₄H₃₀O₁₅

CAS 号

86632-03-3

中文名称

3,4,5-三咖啡酰奎宁酸

结构分类

Phenylpropanoids
Simple Phenylpropanols

Phenols
Polyphenols

来源

Plants
Convolvulaceae
Ipomoea batatas(Linn.) Lamarck

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

-20°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)