Bethanechol chloride (Carbamyl-β-methylcholine chloride) 是一种拟副交感神经药物，是一种 mAChR 激动剂，通过直接刺激副交感神经系统的 mAChR（M1、M2、M3、M4 和 M5）发挥作用。
| Cas No. | 590-63-6 |
| 别名 | 氯贝胆碱; Carbamyl-β-methylcholine chloride |
| 化学名 | 2-carbamoyloxypropyl(trimethyl)azanium;chloride |
| Canonical SMILES | CC(C[N+](C)(C)C)OC(=O)N.[Cl-] |
| 分子式 | C7H17N2O2.Cl |
| 分子量 | 196.68 |
| 溶解度 | ≥ 9.834mg/mL in Water |
| 储存条件 | Store at -20°C |
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
| Shipping Condition | Evaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request |
| 产品描述 | Bethanechol Chloride (Carbamyl-β-methylcholine chloride) is a selective muscarinic receptor agonist without any effect on nicotinic receptors.Target: mAChRBethanechol Chloride (Carbamyl-β-methylcholine chloride) is a parasympathomimetic choline carbamate that selectively stimulates muscarinic receptors without any effect on nicotinic receptors. Unlike acetylcholine, Bethanechol Chloride (Carbamyl-β-methylcholine chloride) is not hydrolyzed by cholinesterase and will therefore have a long duration of action. Oral bethanechol significantly improves contraction pressures and bolus transit in the smooth muscle portion of the esophagus in patients with severe IEM [1]. Bethanechol Chloride (Carbamyl-β-methylcholine chloride) has potential benefit in the treatment of cerebral palsy [2]. References:
[1]. Agrawal, A., et al., Bethanechol improves smooth muscle function in patients with severe ineffective esophageal motility. J Clin Gastroenterol, 2007. 41(4): p. 366-70.
[2]. Carter, W.J., Unexpected benefits of bethanechol in adults with cerebral palsy. Med J Aust, 2008. 189(5): p. 293. |
