Terazosin HCl 是一种喹唑啉衍生物，具有竞争性和口服活性 α1-adrenoceptor 拮抗剂。
| Cas No. | 70024-40-7 |
| 别名 | 盐酸特拉唑嗪(二水合物) |
| 化学名 | [4-(4-amino-6,7-dimethoxyquinazolin-2-yl)piperazin-1-yl]-(oxolan-2-yl)methanone;dihydrate;hydrochloride |
| Canonical SMILES | COC1=C(C=C2C(=C1)C(=NC(=N2)N3CCN(CC3)C(=O)C4CCCO4)N)OC.O.O.Cl |
| 分子式 | C19H25N5O4.HCl.2H2O |
| 分子量 | 459.92 |
| 溶解度 | ≥ 23.0mg/mL in DMSO |
| 储存条件 | Store at -20°C |
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
| Shipping Condition | Evaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request |
| 产品描述 | Terazosin Hydrochloride dihydrate is a selective alpha1-antagonist used for treatment of symptoms of benign prostatic hyperplasia (BPH).Target: Alpha-1 Adrenergic ReceptorTerazosin Hydrochloride dihydrate is an a1-selective blocker. Its inhibitory effect on prostate tumor growth may be the result of antiangiogenic activity. Terazosin Hydrochloride dihydrate is an inhibitor of α1A-AR, α1B-AR, α1D-AR and α2B-AR [1]. References:
[1]. Kyncl, J.J., Pharmacology of terazosin: an alpha 1-selective blocker. J Clin Pharmacol, 1993. 33(9): p. 878-83. |
