Rebamipide (OPC12759) 是一种口服活性胃保护剂，通过诱导 COX-2 表达来增强内源性 PGs（尤其是胃内 PGE2）的产生，从而保护胃粘膜免受损伤。
| Cas No. | 90098-04-7 |
| 别名 | 瑞巴派特; OPC12759; Proamipide |
| 化学名 | 2-[(4-chlorobenzoyl)amino]-3-(2-oxo-1H-quinolin-4-yl)propanoic acid |
| Canonical SMILES | C1=CC=C2C(=C1)C(=CC(=O)N2)CC(C(=O)O)NC(=O)C3=CC=C(C=C3)Cl |
| 分子式 | C19H15ClN2O4 |
| 分子量 | 370.79 |
| 溶解度 | ≥ 10.25mg/mL in DMSO |
| 储存条件 | Store at -20°C |
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
| Shipping Condition | Evaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request |
| 产品描述 | Rebamipide (OPC12759) is a mucoprotective agent. Rebamipide induces COX-2 expression, increases PGE2 levels, and enhances gastric mucosal defense in a COX-2-dependent manner[1]. References:
[1]. Sun WH, et al. Induction of cyclooxygenase-2 in rat gastric mucosa by rebamipide, a mucoprotective agent. J Pharmacol Exp Ther. 2000 Nov;295(2):447-52. |
