ARN-3236是具有口服活性的盐诱导激酶2(SIK2)(IC50<1nM)的选择性抑制剂，具有抑制体内外卵巢癌细胞生长以及增加癌细胞对紫杉醇敏感度的活性。
| Cas No. | 1613710-01-2 |
| 别名 | 3-(2,4-二甲氧基苯基)-4-(3-噻吩基)-1H-吡咯并[2,3-B]吡啶 |
| Canonical SMILES | COC1=CC=C(C2=CNC3=NC=CC(C4=CSC=C4)=C32)C(OC)=C1 |
| 分子式 | C19H16N2O2S |
| 分子量 | 336.41 |
| 溶解度 | DMSO : 130 mg/mL (386.43 mM) |
| 储存条件 | Store at -20°C |
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
| Shipping Condition | Evaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request |
| 产品描述 | ARN-3236 is an oral active and selective inhibitor of salt-inducible kinase 2 (SIK2) (IC50<1 nM), with activity in inhibiting growth and enhancing paclitaxel sensitivity in cultures and xenografts of ovarian cancer cell lines[1][2]. [1]. Lombardi MS, et al. SIK inhibition in human myeloid cells modulates TLR and IL-1R signaling and induces an anti-inflammatory phenotype. J Leukoc Biol. 2016 May;99(5):711-21. [2]. Zhou J, et al. A Novel Compound ARN-3236 Inhibits Salt-Inducible Kinase 2 and Sensitizes Ovarian Cancer Cell Lines and Xenografts to Paclitaxel. Clin Cancer Res. 2017 Apr 15;23(8):1945-1954. |
