Tenidap 是一种非甾体抗炎药，是一种选择性 COX-1 抑制剂，对 COX-1 和 COX-2 的 IC50 值分别为 0.03 μM 和 1.2 μM。
| Cas No. | 120210-48-2 |
| 别名 | 替尼达普,CP-66248 |
| 化学名 | (E)-5-chloro-3-(hydroxy(thiophen-2-yl)methylene)-2-oxoindoline-1-carboxamide |
| Canonical SMILES | ClC1=CC=C(C(/C2=C(C3=CC=CS3)\O)=C1)N(C(N)=O)C2=O |
| 分子式 | C14H9N2O3SCl |
| 分子量 | 320.75 |
| 溶解度 | DMF: 10 mg/ml,DMSO: 20 mg/ml,Ethanol: slightly soluble |
| 储存条件 | Store at -20℃ |
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
| Shipping Condition | Evaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request |
| 产品描述 | Tenidap, a non-steroidal anti-inflammatory drug, is a selective COX-1 inhibitor, with IC50 values of 0.03 μM and 1.2 μM for COX-1 and COX-2, respectively. Tenidap has anti-inflammatory and antirheumatic properties[1][2]. Tenidap is also a specific SLC26A3 inhibitor. References:
[1]. Kirchner T, et al. Evaluation of the antiinflammatory activity of a dual cyclooxygenase-2 selective/5-lipoxygenase inhibitor, RWJ 63556, in a canine model of inflammation. J Pharmacol Exp Ther. 1997 Aug;282(2):1094-101.
[2]. Blackburn WD Jr, et al. Tenidap in rheumatoid arthritis. A 24-week double-blind comparison with hydroxychloroquine-plus-piroxicam, and piroxicam alone. Arthritis Rheum. 1995 Oct;38(10):1447-56. |
