Taccalonolide A

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Taccalonolide A

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CAS NO:

108885-68-3

根薯酮内酯A

Taccalonolide A 是一种微管稳定剂，是从Tacca chantrieri中分离得到的类固醇，具有细胞毒性和抗疟活性。Taccalonolide A 能引起 G₂-M 期滞留、Bcl-2 磷酸化，并引发细胞凋亡。Taccalonolide A 在体外对过表达 p 糖蛋白 (Pgp)、多药耐药蛋白 7 (MRP7) 的细胞系具有显著的抑制作用，抑制 SK-OV-3 细胞生长的 IC₅₀值为 622 nM。

生物活性	Taccalonolide A is a microtubule stabilizer, which is a steroid isolated fromTacca chantrieri, with cytotoxic and antimalarial activities^[1]^[2]. Taccalonolide A causes G₂-M accumulation,Bcl-2phosphorylation and initiation ofapoptosis^[1]. Taccalonolide A is effective in vitro against cell lines that overexpressP-glycoprotein(Pgp) and multidrug resistance protein 7 (MRP7), with an IC₅₀of 622 nM for SK-OV-3 cells^[3].
IC₅₀& Target	microtubule^[1]
分子量	702.74
Formula	C₃₆H₄₆O₁₄
CAS 号	108885-68-3
中文名称	根薯酮内酯A
结构分类	Steroids
来源	Plants Taccaceae Tacca chantrieriAndre
运输条件	Room temperature in continental US; may vary elsewhere.
储存方式	Please store the product under the recommended conditions in the Certificate of Analysis.