Glutaminase C-IN-1 (Compound 968) 是 Glutaminase C 的变构抑制剂，可抑制癌细胞生长而不影响其正常细胞对应物。
| Cas No. | 311795-38-7 |
| 别名 | 5-[3-溴-4-(二甲胺基)苯基]-2,3,5,6-四氢-2,2-二甲基苯并[A]菲啶-4(1H)-酮,Compound 968 |
| Canonical SMILES | O=C1C(C(C2=CC=C(N(C)C)C(Br)=C2)NC3=C4C5=CC=CC=C5C=C3)=C4CC(C)(C)C1 |
| 分子式 | C27H27BrN2O |
| 分子量 | 475.42 |
| 溶解度 | DMSO : 25 mg/mL (52.59 mM) |
| 储存条件 | Store at -20°C |
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
| Shipping Condition | Evaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request |
| 产品描述 | Glutaminase C-IN-1 (968) is an allosteric inhibitor of Glutaminase C that inhibits cancer cell growth without affecting their normal cellular counterparts. References:
[1]. Stalnecker CA, et al. Mechanism by which a recently discovered allosteric inhibitor blocks glutamine metabolism in transformed cells. Proc Natl Acad Sci U S A. 2015 Jan 13;112(2):394-9. |
