Alprostadil (Alprostadil) 是一种前列腺素受体配体，对小鼠 EP3、EP4、EP2、IP 和 EP1 的 Kis 分别为 1.1 nM、2.1 nM、10 nM、33 nM 和 36 nM。
| Cas No. | 745-65-3 |
| 别名 | 前列地尔; Alprostadil; PGE1 |
| 化学名 | 7-[(1R,2R,3R)-3-hydroxy-2-[(E,3S)-3-hydroxyoct-1-enyl]-5-oxocyclopentyl]heptanoic acid |
| Canonical SMILES | CCCCCC(C=CC1C(CC(=O)C1CCCCCCC(=O)O)O)O |
| 分子式 | C20H34O5 |
| 分子量 | 354.48 |
| 溶解度 | ≥ 13.4mg/mL in DMSO |
| 储存条件 | Store at -20°C, stored under nitrogen,unstable in solution, ready to use. |
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
| Shipping Condition | Evaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request |
| 产品描述 | Prostaglandin E1 (PGE1) is a potent vasodilator and activates the prostaglandin E1 (EP) receptor. References:
[1]. Cawello W, et al. Dose proportional pharmacokinetics of alprostadil (prostaglandin E1) in healthy volunteers following intravenous infusion. Br J Clin Pharmacol. 1995 Sep;40(3):273-6.
[2]. Roehl SL, et al. Alprostadil (Prostin VR Pediatric Sterile Solution, The Upjohn Company). Drug Intell Clin Pharm. 1982 Nov;16(11):823-32.
[3]. Harding LM, et al. Comparison of a needle-free high-pressure injection system with needle-tipped injection of intracavernosal alprostadil for erectile dysfunction. Int J Impot Res. 2002 Dec;14(6):498-501. |
