CAY10471 (TM30089) 是一种有效的、选择性的、具有口服活性的前列腺素 D2 受体 CRTH2 拮抗剂。
| Cas No. | 627865-18-3 |
| 别名 | TM30089 |
| 化学名 | (+)-3-[[(4-fluorophenyl)sulfonyl]methylamino]-1,2,3,4-tetrahydro-9H-carbazole-9-acetic acid |
| Canonical SMILES | CN(S(C1=CC=C(F)C=C1)(=O)=O)C(CC2)CC3=C2N(CC(O)=O)C4=CC=CC=C43 |
| 分子式 | C21H21FN2O4S |
| 分子量 | 416.5 |
| 溶解度 | DMSO : 150 mg/mL (360.17 mM) |
| 储存条件 | Store at -20°C |
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
| Shipping Condition | Evaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request |
| 产品描述 | The biological effects of prostaglandin D2 are transduced by at least two 7-transmembrane G-protein coupled receptors, designated DP1 and CRTH2/DP2. BAY-u3405 (Ramatroban) is an approved human medication for the treatment of allergic rhinitis that has documented activity as an antagonist of both the TP and CRTH2/DP2 receptors. CAY10471 is an analog of BAY-u3405 which contains modifications that increase both its potency and selectivity for the human CRTH2/DP2 receptor. CAY10471 binds to the human CRTH2/DP2, DP1, and TP receptors with Ki values of 0.6, 1200, and >10,000 nM, respectively. |
