STINGagonist-16 (1a) is a specific stimulator of interferon genes (STING) agonist.STINGagonist-16 (1a) can be used as a potential antiviral and antitumor tool^[1].

STING agonist-16 (1a) (0-100 μM, 6 h) can promote mRNA expression of IFNβ, CXCL-10 and IL-6 in a dose-dependent manner with no significant cytotoxic effect up to 100 μM in human myeloid leukemia mononuclear cells (THP1)^[1].
STING agonist-16 (1a) (50 μM, 2 h) significantly induces the phosphorylation of STING, TANK-binding kinases1 (TBK1) and interferon regulatory factor 3 (IRF3) in THP1 cells^[1].
STING agonist-16 (1a) activates secretory alkaline phosphatase (SEAP) in a dose-dependent manner with an EC₅₀value of 16.77 μM while 2'3'-cGAMP acts with an EC₅₀value of 9.212 μM^[1].

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