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Methylene Violet 3RAX
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Methylene Violet 3RAX图片
CAS NO:4569-86-2

Methylene Violet 3RAX 是一种吩嗪染料,用于染色细胞的线粒体。Methylene Violet 3RAX 可以改变DNA的分子结构,破坏DNA的模块,诱导活性单线态氧的产生。Methylene Violet 3RAX 对人红细胞 AChE 和人血浆 BChE 具有抑制作用,Kis 分别为 1.58 和 0.51 μM。Methylene Violet 3RAX 具有研究PDT (光动力疗法) 中线粒体靶向作用的潜在光敏剂的潜力。
生物活性

Methylene Violet 3RAX is a phenazine dye to stain the mitochondria of cells. Methylene Violet 3RAX can change the molecular structure of DNA, undermine the module of DNA, and induce the generation of the reactive singlet oxygen. Methylene Violet 3RAX shows inhibition for human erythrocyteAChEand human plasmaBChEwith anKis of 1.58, 0.51 μM, respectively. Methylene Violet 3RAX has the potential for the research of potential photosensitizers for mitochondrial targeting action in PDT (photodynamic therapy)[1][2].

IC50& Target[2]

BChE

0.51 μM (Ki)

AChE

1.58 μM (Ki)

体外研究
(In Vitro)

Methylene Violet 3RAX shows antitumor activity by cutting off DNA strands in tumour cell[1]. Methylene Violet 3RAX (0-400 μM) significantly enhances cleavage of DNA with over 60% photocleavage activity towards DNA at 300 μM[1].

分子量

378.90

Formula

C22H23ClN4

CAS 号

4569-86-2

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

 
 
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