PROTAC CYP1B1 degrader-1

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本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。

CAS NO:

2411389-67-6

PROTAC CYP1B1 degrader-1 (Compound 6C) 是一种 α-萘黄酮嵌合衍生物，能够通过靶向CYP1B1降解消除细胞色素 P450 (CYP)1B1 介导的耐药性，对 CYP1B1 和 CYP1A2 的IC₅₀分别为 95.1 和 9838.6 nM。PROTAC CYP1B1 Degrader-1 可用于研究CYP1B1过表达的前列腺癌。

生物活性	PROTACCYP1B1 degrader-1 (Compound 6C), a α-naphthoflavone chimera derivative, is able to eliminatecytochrome P450(CYP)1B1-mediated drug resistance via targetedCYP1B1degradation, withIC₅₀s of 95.1 and 9838.6 nM for CYP1B1 and CYP1A2, respectively.PROTACCYP1B1 degrader-1 can be used for the research of CYP1B1-overexpressing prostatecancer^[1].
分子量	785.80
Formula	C₄₃H₃₉N₅O₁₀
CAS 号	2411389-67-6
运输条件	Room temperature in continental US; may vary elsewhere.
储存方式	Please store the product under the recommended conditions in the Certificate of Analysis.