PXS-6302

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PXS-6302

本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。

CAS NO:

2584947-54-4

PXS-6302 是一种不可逆赖氨酸氧化酶 (LOX) 抑制剂，IC₅₀分别为 3.7 μM (Bovine LOX)，3.4 μM (rh LOXL1)，0.4 μM (rh LOXL2)，1.5 μM (rh LOXL3)，0.3 μM (rh LOXL4)。PXS-6302 易穿透皮肤，能够减少胶原蛋白沉积，显著改善疤痕外观。

生物活性

PXS-6302 is an irreversiblelysyl oxidaseinhibitor withIC₅₀s of 3.7 μM (Bovine LOX), 3.4 μM (rh LOXL1), 0.4 μM (rh LOXL2), 1.5 μM (rh LOXL3), 0.3 μM (rh LOXL4), respectively. PXS-6302 has readily skin penetrability, reduces collagen deposition and significantly improves scar appearance^[1].

IC₅₀& Target

3.7 μM (Bovine LOX), 3.4 μM (rh LOXL1), 0.4 μM (rh LOXL2), 1.5 μM (rh LOXL3), 0.3 μM (rh LOXL4)^[1]

体外研究
(In Vitro)

PXS-6302 demonstrates high permeability to across a monolayer of cells, such as Caco-2 or MDCKII cells^[1].

体内研究
(In Vivo)

PXS-6302 inhibits LOX, reduces crosslinking and improves scar appearance in porcine models of excisional and burn injury^[1].
PXS-6302 (1.5%, oil in water cream; 500 mg cream applied to 16 cm²; external application; once daily, for 28 days) reduces collagen deposition and cross-linkin in murine models of injury and fibrosis under topical application^[1].
PXS-6302 (0.5, 1.5, or 3%, oil in water cream; 400 mg cream applied to 16 cm²; external application; once daily, for 12 weeks) also significantly improves scar appearance without reducing tissue strength in porcine injury models under topical application^[1].

Animal Model:	Porcine excision injury model (female Juvenile pigs, 18-20 kg)^[1]
Dosage:	0.5, 1.5, or 3%, oil in water cream; 400 mg cream applied to 16 cm²
Administration:	External application; 1, 2 and 3 weeks post-injury; once dayly, for 12 weeks
Result:	Showed significantly higher scores for the 3% treated scars suggesting significant improvement in scar appearance.

分子量

265.25

Formula

C₁₀H₁₀F₃NO₂S

CAS 号

2584947-54-4

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.