BAY-7598

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BAY-7598

本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。

CAS NO:

1816257-74-5

BAY-7598 是一种有效的，具有口服活性的选择性MMP12抑制剂探针，对人 MMP12，小鼠 MMP12 和大鼠 MMP12 的IC₅₀分别为 0.085，0.67 和 1.1 nM。具有抗炎活性。

生物活性

BAY-7598 is a potent, orally bioavailable, and selectiveMMP12inhibitor probe withIC₅₀s of 0.085, 0.67 and 1.1 nM for human MMP12, murine MMP12, and rat MMP12, respectively^[1].

IC₅₀& Target

IC50: 0.085 nM (human MMP12), 0.67 nM (murine MMP12), 1.1 nM (rat MMP12)^[1]

体外研究
(In Vitro)

BAY-7598 inhibits human MMP2, MMP3, MMP7, MMP8, MMP9, MMP10, MMP13, MMP14, and MMP16 with IC₅₀s of 44, 360, 600, 15, 460, 12, 67, 250, and 940 nM, respectively^[1].
BAY-7598 inhibits murine MMP2, MMP3, MMP7, MMP8, and MMP9 with IC₅₀s of 45, 270, 130, 54, and 210 nM, respectively^[1].
BAY-7598 inhibits rat MMP2, MMP8, and MMP9 with IC₅₀s of 45, 67, and 1000 nM, respectively^[1].

体内研究
(In Vivo)

BAY-7598 has moderate terminal elimination half-life (t_1/2=4.6 h and 4.1 h for mouse (0.3 mg/kg, iv), mouse (5.0 mg/kg, p.o.) , respectively)^[1].

Animal Model:	Mouse^[1]
Dosage:	0.3 mg/kg (i.v.) and 5.0 mg/kg (p.o.)
Administration:	Administered i.v. (0.3 mg/kg) and p.o. (5.0 mg/kg) (Pharmacokinetic Analysis)
Result:	T_1/2=4.6 h and 4.1 h for 0.3 mg/kg (i.v.) and 5.0 mg/kg (p.o.), respectively.

分子量

505.56

Formula

C₂₈H₃₁N₃O₆

CAS 号

1816257-74-5

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.