(R)-(+)-Dimethindene maleate

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CAS NO:

136152-64-2

(R)-(+)-Dimethindene maleate 是一种具有口服活性的H₁-receptor阻断剂，对猪具有抗组胺性能。

生物活性

(R)-(+)-Dimethindene maleate is an orally activeH₁-receptorblocker with antihistaminic properties in pigs^[1].

IC₅₀& Target^[1]

H₁Receptor

7.7 (pA2)

体外研究
(In Vitro)

(R)-(+)-Dimethindene maleate possesses membrane-stabilising effect^[1].

体内研究
(In Vivo)

(R)-(+)-Dimethindene maleate (10 mL/kg; i.g.; once) shows antihistaminic activity with an ED₅₀of 2.73 mg/kg in pigs^[1].

Animal Model:	Male guinea-pigs^[1]
Dosage:	10 mL/kg
Administration:	Oral gavage, once
Result:	The ED₅₀-value for a protection from a fatal histamine shock was calculated as 2.73 mg/kg when administered orally 1 h before the injection of histamine. The calculated oral anti-anaphylactic ED₅₀-value was found to be >31.6mg/kg. The oral LD₅₀-values was found to be 988 mg/kg.

分子量

408.49

Formula

C₂₄H₂₈N₂O₄

CAS 号

136152-64-2

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

溶解性数据

In Vitro:

DMSO : 100 mg/mL(244.80 mM;Need ultrasonic)

配制储备液

浓度溶剂体积质量

1 mg

5 mg

10 mg